For example, Cai et al. indicated that GPX3 prevented migration and invasion of gastric cancer by targeting NF-kB/Wnt5a/JNK signaling [20]; Lee et al. suggested that GPX3 arrested cell cycle and functioned as a tumor suppressor in lung cancer [21]; Hua et al. showed that silencing GPX3 expression promoted tumor metastasis in human thyroid cancer [22]; Caitlyn et al. revealed that plasma GPX3 limited the development of colitis -associated carcinoma [23]. This evidence concerns the gene NFKB1 and thyroid gland carcinoma.