Moreover, in vivo experiments have shown that AQP1 deficiency can reduce tumor mass, volume, vessel density and lung metastases in MMTV-PyVT (mouse mammary tumor virus-driven polyoma virus middle T oncogene) mice, and inhibition of AQP1 function and/or expression is predicted to attenuate angiogenesis via reduced migration and invasion of endothelial cells [30]. This evidence concerns the gene AQP1 and neoplasm.