HRH3 and Prader-Willi syndrome: In all cases, inhibition of radioligand binding to the off-targets was lower for UNC-0642 and A-366 when compared with the respective positive controls at such receptors and also lower when compared to their inhibitory activity at H3R. In essence, one could hypothesize an additional action of agonists at D2R would have beneficial effects for PWS due to a suppressed food-intake in vivo24.