OXTR and Familial prostate cancer: Indeed, OTR coupling to Gαi seems to be especially important in mediating the inhibition of cell growth [115], and independent activation of either Gαi1 (by DNalOVT) or Gαi3 (by AT) can lead to growth inhibition in cells expressing a functional Gαi-coupled OTR (HEK293 cells stably expressing the OTR-enhanced green fluorescent protein and DU145 human prostate cancer cells expressing endogenous OTR) [99].