BRCA1 and melanoma: Of the 17 RC cases with a BRCA1 or BRCA2 PV, 8 (47.1%, 8/17) had an additional cancer associated with hereditary breast and ovarian cancer (HBOC) syndrome (breast, ovarian, prostate, pancreatic or melanoma), 3 had an additional non-HBOC cancer (17.6%, 3/17), and 6 presented with only eoRC (35.3%, 6/17) (Table 2).