SYP and cancer: It would next be pertinent to determine whether an analogous mechanism involving target-specific retrograde AA signaling and Syp-dependent inhibition of LDCV fusion may be involved in expressing gastric mill motor patterns in the Cancer STG, and whether this may be a more general mechanism for the target-specific regulation of cotransmitter release underlying the appropriate expression and context-dependent plasticity of patterned motor behaviours across species.