Because Galectin-1 and -3 binding of glycoconjugates on tumor cells mediates many key processes in angiogenesis and elevated levels of Galectin-1 and -3 in the endothelium are correlated with tumor vascularization,105,128–131 the promotion of tumor vascular remodeling by tumor CD146 may be due to the interactions between CD146 with Galectin-1 and -3. Here, MCAM is linked to neoplasm.