LGALS1 and cancer: Among them, Galectin-1, -3, and -9 are three best-investigated galectins and Galectin-1 and -3 promote tumor development, progression, and immune escape.90 Galectin-1 and -3 can hamper antitumor responses and are considered multifunctional targets for cancer therapy.91,92 The underlying mechanisms include interfering with drug efficacy/delivery or reducing the antitumor effect of immune cells.