In 2016, Ruma et al. revealed that S100A8/A9 uses CD146 as a receptor during lung-specific metastasis of melanoma cells.175 In this study, they demonstrated that S100A8/A9 binding to CD146 activates nuclear factor-kappa B (NF-κB) and induces reactive oxygen species formation, significantly increasing cell adhesion, growth, and invasion. The gene discussed is S100A8; the disease is melanoma.