The endothelial galectins are confined to four family members, i.e., Galectin-1, -3, -8, and -9, which contribute to tumor angiogenesis.92 Tumor-induced angiogenesis is a pathologic condition in which tumor cells secrete growth factors, such as VEGFs, to promote the growth of new blood vessels.125,126 These growth factors activate quiescent endothelial cells in host tissue to facilitate them to invade into the tumor stroma for growth of new capillaries.127 Endothelial galectins binding with glycoconjugates on tumors are involved in different processes during tumor-induced angiogenesis. Here, LGALS1 is linked to neoplasm.