MCAM and carcinoma: This investigation is consistent with the observation that the α4-laminins, including Laminins 411 and 421, expressed and secreted by various carcinoma cells, have already emerged as “onco-laminins.”67–72 Melanoma CD146 binds with Laminin 421 but not 411, whereas lymphocyte CD146 only binds with Laminin 411; suggesting that the epitopes of CD146 on somatic cancer cells are different from those of CD146 on blood lymphocytes.