CD146 is a reliable biomarker of endothelia and is concentrated at the intercellular junctions of endothelial cells of vessel system.21 Most cancer cells, including melanoma, migrate along the abluminal sides of vascular and/or lymphatic vessels, as they disseminate throughout the body.83 Laminin 421 is major laminins of along the tumor-dissemination tracks (blood and lymphatic vessels, nerves, and tumor stroma).84–86. Here, MCAM is linked to cancer.