MCAM and cancer: Because both CD146 and PDGFR-β are involved in regulation of growth and survival of different cell types, including cancer cells, further investigation of functions of CD146 and PDGFR-β interaction in cancers may help deeply understand the dysregulation of spatio-temporally controlled PDGF-BB induced signaling during tumor development and progression, especially tumor angiogenesis and lymphangiogenesis.