MCAM and melanoma: In 2015, Yazawa et al. thus further analyzed the functions of this interaction on melanoma and found that when Galectin-1 binds to CD146, it helps maintain intrinsic malignant features.108 The authors examined the expression, identity, and function of Galectin-1 ligands in melanoma progression and demonstrated that CD146 is the major Galectin-1 ligand on melanoma cells.