These findings that CD146, as a novel receptor for S100A8/A9, mediates the transition of malignant cancers to metastatic sites, suggest that strategies modulating the interaction between CD146 and S100A8/A9 may be useful for interference with cancer metastasis, especially in the progression of pre-metastatic tumors to the lungs. This evidence concerns the gene IGKV1D-22 and cancer.