Notably, this study proposed that CD146 governs cancer invasion toward the lungs by sensing the cancer microenvironment as a soil sensor receptor of lung S100A8/A9.175 Therefore, the authors conclude that S100A8/A9 plays a crucial role in lung tropic cancer metastasis by helping to establish an immunosuppressive metastatic niche, to which it then attracts remote cancer cells by interacting with CD146 on the cancer cell surfaces. Here, S100A8 is linked to cancer.