FLT1 and hepatocellular carcinoma: Tivozanib is another oral inhibitor of VEGFR-1/2/3 with promising activity against HCC in vivo (NCT01835223) and TRC105, which despite demonstrating clinical activity and being well tolerated in HCC patients following sorafenib, has not to date met prespecified criteria and its development in HCC continues as combination therapy with sorafenib (NCT02560779).