Serum levels of PIVKA-II and AFP and the serum γ-GT/ALT ratio in patients with HCC who were negative for HBV DNA were higher than those in patients with CHB who were negative for HBV DNA (P < 0.001, P < 0.001, P < 0.001; Fig. 5A–C). The gene discussed is GPT; the disease is hepatocellular carcinoma.