AFP and hepatocellular carcinoma: When the cut-off values of the γ-GT/ALT ratio, AFP levels, and PIVKA-II levels were set as 1.400, 761.45 ng/mL, and 87.63 mAu/mL, respectively, for patients with HCC who were negative for HBV DNA, the AUROCs of both the γ-GT/ALT ratio and PIVKA-II were higher than that of AFP (P < 0.001, P < 0.001, respectively).