Further analysis showed that the diagnostic sensitivity of PIVKA-II was significantly higher than that of the γ-GT/ALT ratio and AFP for HCC, HCC (HBV DNA+), and HCC (HBV DNA−), whereas the γ-GT/ALT ratio and the level of PIVKA-II in the serum had the same sensitivity for the diagnosis of early-stage HCC. Here, GPT is linked to hepatocellular carcinoma.