This identified several host kinases as potential targets for HDT; on this basis, we further demonstrate that selective inhibitors against human c-MET and B-Raf display high potency against P. falciparum and P. knowlesi in vitro, and show that a c-MET inhibitor has in vivo activity against Plasmodium berghei in a murine model of malaria. Here, MET is linked to malaria.