Several selective inhibitors of c-MET and B-Raf have emerged from the cancer drug discovery pipeline, allowing us to measure the IC50 values in parasite proliferation assays of the following inhibitors: Crizotinib (an inhibitor of c-Met and the related receptor tyrosine kinase ALK [anaplastic lymphoma kinase]), PHA-665752 (a c-MET-selective inhibitor), SB-590885 (a B-Raf selective inhibitor) and Sorafenib (a B-Raf inhibitor, which also targets C-Raf, albeit with a tenfold lower potency)50 (Fig. 6b, c). The gene discussed is BRAF; the disease is cancer.