Pre-clinical and clinical studies have indicated that the CXCR4 blockade enhances the infiltration of TIL and reduces the immunosuppressive cells in the tumor microenvironment, thus converting the tumor from “cold” to “hot.” BL-8040 is a high-affinity peptide with a long receptor occupancy of CXCR4. The gene discussed is CXCR4; the disease is neoplasm.