CLOCK and infection: To probe how core-TTFL clock-controlled host rhythms and host-feeding-related rhythms influence the IDC schedule, we apply time-restricted feeding (TRF) protocols to wild-type (WT) mice and clock-disrupted Per1–Per2 double knockout mice (Per1/2-null) and compare the consequences for the IDC schedule of P. chabaudi infections initiated with either synchronous or desynchronized parasites.