MAPT and Alzheimer disease: The classic neuropathological lesions in AD consist of (i) aggregated amyloid plaques containing extracellular hydrophobic deposition of amyloid β peptides (Aβ) in the neuronal body, and (ii) neurofibrillary tangles composed of aggregates of hyperphosphorylated and misfolded tau protein (a microtubule-associated protein) that appear within the neurons [8].