SF3B1 and neoplasm: Mutually exclusive mutations in two other genes, eukaryotic translation initiation factor 1A (EIF1AX) and splicing factor 3 subunit 1 (SF3B1), have allowed further subdivision of the low metastatic risk D3 group, with EIF1AX mutations associated with non-metastasising tumours [20,22], whereas SF3B1 mutations are associated with a delayed metastatic onset (intermediate risk) [11,23].