Research on cervical squamous carcinoma cells [46], hepatocellular carcinoma [143], lung adenocarcinoma [13], and uveal melanoma [159] shows that chronic hypoxia does not affect CCL7/MCP-3 expression due to the lack of an HRE sequence in the promoter region of the CCL7 gene [184]. The gene discussed is CCL7; the disease is lung adenocarcinoma.