CCL18 and hepatocellular carcinoma: On the other hand, in lung adenocarcinoma cells [13] and hepatocellular carcinoma cells [143], hypoxia does not change the expression of CCL18/MIP-4, probably because of the low expression of this chemokine in cancer cells compared to TAM which have the highest synthesis of CCL18/MIP-4 in a tumor [102,238,239].