Unfortunately, it was not possible to analyze the effects of the mAbs on the other pathways downstream CTLA-4 in CD8+ T cells, as shown before for tumor and NK cells, since the isolated CD8+ cells were not significantly stimulated with SEB (under the conditions used for activating NK cells) either in the absence or in the presence of the mAbs (Supplementary Figure S3). The gene discussed is CD8A; the disease is neoplasm.