CTLA4 and neoplasm: Unfortunately, it was not possible to analyze the effects of the mAbs on the other pathways downstream CTLA-4 in CD8+ T cells, as shown before for tumor and NK cells, since the isolated CD8+ cells were not significantly stimulated with SEB (under the conditions used for activating NK cells) either in the absence or in the presence of the mAbs (Supplementary Figure S3).