TMEM59 and cystic fibrosis: Other than increasing IL1β, a primary cytokine in CF disease and its defective response to infection [45,46], Myr upregulated the expression of the transmembrane protein TMEM59, which induces the LC3 labelling of endosomal vesicles, stimulating their fusion with lysosomes, in response to autophagy and xenophagy [47].