ACE2 and vasculitis: Although the possibility of intracranial hemorrhage due to underlying vasculitis is valid even without evidence of vascular pathologies [30,31], we think other explanations should be entertained: The SARS-CoV-2 uses Angiotensin-converting enzyme 2 (ACE2) receptors expressed by pneumocytes in the epithelial alveolar lining to infect the host, thereby causing lung injury, but studies demonstrate also a wide expression of the ACE2 receptor on endothelial cells in the brain [6,32].