Moreover, the detected pathways from the results of the Ivy Glioblastoma Atlas suggest that different pathways are involved, including that of neuronal development in the leading edge, precursors differentiation in the cellular tumour, the hypoxia inducible factor (HIF) system in PAN, and the tumour necrosis and HIF in MVP, which also displayed a hyperactivation of PI3K/AKT/mTOR signalling [53]. This evidence concerns the gene MTOR and neoplasm.