PAK1 and adrenal cortex carcinoma: In ACC, in vitro overexpression of miR-7 decreases proliferation and induces G1 cell cycle arrest and decreases the expression of p21 activated kinase 1 (PAK1), CDC28 protein kinase regulatory subunit 2 (CKS2), and cyclin-dependent kinase 1 (CDK1) mRNA [121].