Both LOH [17] and paternal uniparental disomy at the 11p15 locus result in IGF2 overexpression and reduced expression of H19 and Cyclin-dependent kinase inhibitor 1C (CDKN1C) in ACC [36], which are associated with poor prognosis and increased rates of recurrence [43]. This evidence concerns the gene CDKN1C and adrenal cortex carcinoma.