DICER1 and adrenal cortex carcinoma: In a study which compared the expression of key miRNA processing factors between 29 ACC and 43 adrenocortical adenoma (ACA) tissues, Caramuta and colleagues showed that DICER, DROSHA, and TAR RNA-binding protein 2 (TARBP2) (a DICER cofactor required for miRNA processing [57]) were overexpressed at the mRNA and protein levels in ACC compared with ACA [58].