The immune system is responsible for the resolution of COVID-19, however, overactivation of the immune system against SARS-CoV-2 can result in a severe cytokine storm due to the release of huge numbers of inflammatory factors such as IL-2, IL-6, IL-7, GM-CSF, IP10, MCP1, MIP1A, and TNF-α [35,36]. This evidence concerns the gene CSF2 and COVID-19.