They suggest that (1) myopic elongation stretches the retinal tissue, resulting in decreased vascular endothelial growth factor production and a putative decrease in retinal microvascular density [29,37]; (2) the decrease is vascular density may be a result of reduced oxygen demand because of myopic retinal degeneration; (3) RNFL loss may reduce regional oxygen demand, thus triggering retinal vascular attenuation via auto-regulatory mechanisms [23,29]. The gene discussed is VEGFA; the disease is retinal degeneration.