Furthermore, arthralgia was found to be significantly associated with the increase of serum concentrations of inflammatory biomarkers, such as C reactive protein (CRP), eotaxin, monocyte chemoattractant protein (MCP)-1 and vitamin D-binding protein (VDBP), in a cross-sectional study of 203 women taking AIs for early BC [82]. The gene discussed is CRP; the disease is breast cancer.