In 2016, Mascella et al. [132] reported a case of ASAS after treatment with AIs, in a BC patient with a previous diagnosis of RA, who developed a severe bilateral interstitial pneumonia and necrotizing myopathy, associated with a creatine kinase increase and positivity of anti-Jo1 and anti-Ro52 antibodies, after 3 months of therapy with Letrozole. Here, TRIM21 is linked to breast cancer.