In particular, the thiazolidin-4-ones, a privileged pharmacophore possesses an array of biological activities including anti-inflammatory [9], antimicrobial [10], antibiofilm [11], antiparasitic [12], anticancer [13], anti-viral [14], antidiabetic [15], antiarthritic [16], FSH agonist [17], JNK stimulating phosphatase-1 (JSP-1) [18], CNS-penetrant [19], CDK1/Cyclin B inhibition [20], COX-2 inhibitor [21] and hypoglycemia [22] properties. This evidence concerns the gene DUSP22 and Hypoglycemia.