CASP3 and breast carcinoma: In the breast cancer cohort, the study assessed if the effect of FEC-T (5-fluorouracil, epirubicin, cyclophosphamide and docetaxel) neoadjuvant treatment on [18F]ICMT-11 uptake correlated with blood cytokeratin-18 assessment and biopsy-derived caspase-3/7 tissue expression following chemotherapy.