In CCA, the CD14+/CD16+ TAM population derives from circulating monocytes and not from Kupffer liver cells [58,59] and they are attracted to the CCA TME by the chemokine (C–C motif) ligand 2 (CCL2) released by CAFs [60], TAN and liver-residing macrophages [61]. This evidence concerns the gene CCL2 and cholangiocarcinoma.