Besides the direct impact on tumor cells by regulating their proliferation, survival and migration, CAFs regulate angiogenesis and immunity by secreting a vast number of soluble chemokines and growth factors, such as chemokine (C-X-C motif) ligand 14 (CXCL14), interleukin 8 (IL-8), IL-13, vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF), that stimulate stromal cells and recruit inflammatory immune cells in tumor bed [26]. Here, CXCL8 is linked to neoplasm.