In CCA, tumor cells are a reservoir of protumorigenic and immunosuppressive molecules, such as IDO, IL-10, and TGF-β [61,80], which participate in the immunosuppression of the effector CTL and the attraction of innate immune cells as TAN, TAM, MDSC, and Treg. This evidence concerns the gene TGFB1 and cholangiocarcinoma.