Next, we evaluated whether the activity of NF-κB p65 subunit (which is very important in the canonical pathway), as measured by its ability to bind to the DNA oligonucleotide 5′-GGGACTTTCC-3′, differed between healthy subjects and patients with MS, since one previous publication has suggested that no differences occur [11]. Here, NFKB1 is linked to myeloid sarcoma.