Both SAT and VAT highly expressed TNFα, IL‐1β, and IL‐6, which was strongly reduced after successful weight loss.(23, 28) Similarly, adiponectin and leptin (prototypic immunomodulatory adipokines) are critically involved in AT inflammation and obesity‐related disorders.(29) Collectively, these studies highlight the importance of cellular, cytokine, adipokine. This evidence concerns the gene IL1B and obesity disorder.