Finally, the enrichment of antigen processing and presentation pathway and significantly reduced expression of genes coding for the cluster of differentiation 14 (CD14), which was already proved to be differentially expressed in metformin-treated monocyte cells, and the cluster of differentiation 163 (CD163) [47], a scavenger receptor which has been previously associated with insulin resistance in patients with T2DM, altogether may explain well-known participation of metformin in the inflammatory and immune responses [48]. The gene discussed is CD14; the disease is Insulin resistance.