Although numerous reports have shown that lysosomal inhibition or deletion of autophagy genes can impair tumor growth in MAPK-mutant cancers (22) as single agents, in some contexts, deletion of autophagy genes, such as Atg7, is well tolerated by tumor cells, and in most models HCQ does not produce single-agent antitumor activity (23). Here, ATG7 is linked to neoplasm.