To further understand if mitophagy supports TAMs’ survival by eliminating ROS in the tumor microenvironment, we compared the levels of cell apoptosis and ROS production between Tim-4+Fip200–/– TAMs and Tim-4–Fip200–/– TAMs because they showed different levels of damaged mitochondria accumulation (Figure 6A). This evidence concerns the gene TIMD4 and neoplasm.