ZHX2 can enhance the nuclear translocation of NF‐κB and promote tumorigenesis in renal cell carcinoma,15 however, studies also show that ZHX2 is a tumor suppressor in lung cancer and hepatocellular carcinoma,16, 17 therefore it is still unknown that the role of ZHX2 in myeloma. Here, ZHX2 is linked to plasma cell myeloma.