PLN and cardiomyopathy: Examples in the cardiomyopathy field of genotype-specific treatment can be found in dilated cardiomyopathy, where LMNA or PLN mutation associated cardiomyopathies are associated with an ‘arrhythmogenic phenotype’ mandating early ICD implant, at left ventricular ejection fraction (LVEF) of ≤45%, instead of the usual LVEF ≤35% cut-off in other subtypes [23].