PAR1-1 is activated by MMP1 and this activation induces the secretion of angiogenic factors IL-8 and growth-regulated oncogene-α (GRO-α) from ovarian carcinoma cells, which act on endothelial CXCR1/2 receptors in a paracrine manner, leading to endothelial cell proliferation, tube formation and migration [207]. Here, MMP1 is linked to ovarian carcinoma.