Thus, the present study suggests that the mitochondrial SOD1 mutants not only induce mitochondrial toxicity, but also inhibit the mitophagy process, which may contribute to mitochondrial pathology observed in ALS patients or SOD1 mutants transgenic mouse models (Tan et al., 2014; Xie et al., 2015). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.