TRPC6 and clear cell renal carcinoma: In addition, overexpression of TRPC6 in turn resulted in the nuclear translocation of NFAT (Figure 7D, D1, D2 and E), suggesting this feedback loop between NFATc1 and TRPC6 exists in tubular cells in DN, like in podocytes, cardiomyocytes and clear cell renal cell carcinoma (ccRCC) cells.23, 49, 50, 51