Case 2 involved several ultrasound abnormalities including oligohydramnion, bilateral echogenic kidneys, bilateral hydronephrosis, megalo‐ureter, and megabladder and was detected of a de novo nonsynonymous SNV (c.536G > A; p.R179H) in exon6 of ACTA2 gene. The gene discussed is ACTA2; the disease is hydronephrosis.