In NIH-3T3 cells stably expressing US28, HEK-293T transiently transfected with US28, and in HCMV-infected malignant glioblastoma U373MG cells, the constitutive activation of Gαq by US28 is reported to enhance cell proliferation and DNA synthesis by activating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) leading to secretion of IL-6 inducing STAT3 phosphorylation via Janus kinase 1 (JAK1) [27] (Figure 2). The gene discussed is STAT3; the disease is glioblastoma.