STAT3 activation by US28-mediated IL-6 secretion was also reported to be involved in VEGF production in NIH-3T3 cells stably transfected with US28 and U373MG cells 48 h after infection with HCMV as well as in primary glioblastoma specimens from patient samples [27] (Figure 2). Here, IL6 is linked to glioblastoma.