In line with these observations, it was reported that in human foreskin fibroblasts and human glioblastoma U373MG cells infected with HCMV, the constitutive activation of Gαq and G proteins from the Gα12/13 family by US28 induces activation of β-catenin in a PLCβ-independent manner via activation of Rho and ROCK [28] (Figure 2). Here, GNAQ is linked to glioblastoma.