Additionally, some studiesshowed that HLA expression changes like HLA-A 02:02,HLA-B 15:03, HLA-C 12:03, HLA-B 54:01, HLA-B07:03, HLA-Cw 08:01, DRB1 03:01, and especiallyHLA-B 46:01 were significantly associated with highriskrespiratory infectious diseases, like severe acuterespiratory syndrome (SARS), middle east respiratorysyndrome (MERS) and flu. This evidence concerns the gene HLA-B and infectious disease.