Some studies showed that circulating levels ofeNAMPT/visfatin are elevated in NAFLD (24, 25).Conversely, downregulation of iNAMPT was recentlyreported in hepatic tissue of patients with NAFLD (23).Taken together, these studies point to the involvementof NAMPT in the pathogenesis of NAFLD; however,the associated molecular and metabolic mechanisms arenot fully elucidated. This evidence concerns the gene NAMPT and metabolic dysfunction-associated steatotic liver disease.