Overexpression of GATA5 played a role instimulating Paclitaxel to inhibit growth, colony formation and migration, as well as enhance apoptosis in HCC cells.Overexpression of GATA5 also promoted Paclitaxel to inhibit expression of reprogramming genes, such as Nanog,EpCAM, c-Myc and Sox2 in Bel7402 and PLC/PRF/5 cells. Here, SOX2 is linked to hepatocellular carcinoma.