The cell migrationand invasion assay indicated that GATA5 synergizedwith Paclitaxel to significantly reduce pore migratorycapacity of the HCC cells and overexpression of GATA5enhanced Paclitaxel to inhibit expression of the migrationrelatedfactors, MMP2 and MMP9. This evidence concerns the gene MMP2 and hepatocellular carcinoma.