Furthermore, circulating plasma Adiponectin levels and expressions of bothAdipoRs are reduced in the subjects with a family history of T2D (32).Based on the incidence of insulin resistance in aged rats and previous data, it wasconcluded that circulating Adiponectin level was reduced with age, indicating thatAdiponectin probably played an important role in aging-related diseases, such as insulinresistance. This evidence concerns the gene ADIPOQ and Insulin resistance.