In this experimental study, insulin resistance markers including serum insulin and glucoseconcentrations, homeostatic model assessment of insulin resistance (HOMA-IR), oral glucose tolerance test (OGTT),glucose induced insulin secretion (GIIS), serum Adiponectin levels, pancreatic expression of Adiponectin and itsreceptors were studied in male Sprague-Dawley rats at the age of 2, 5, 10, 18, 52 and 72 weeks of age. Here, INS is linked to Insulin resistance.