Moreover, it waspreviously shown that autologous ADSCs have the ability to secret many potent angiogenic factors includingvascular endothelial growth factor (VEGF), fibroblastgrowth factor (FGF), and insulin growth factor-1 (IGF-1)and may also play an important role in enhancement ofangiogenesis and anti-apoptotic ability in diabetes (9, 10).Consequently, loss of action or functional impairmentof dADSCs may be responsible for some of the diabetescomplications. This evidence concerns the gene IGF1 and diabetes mellitus.