The correlation data revealed a strong positive correlation between markers of sepsisseverity (MSS and lactate) and inflammatory and brain injury markers but a negativecorrelation with Cldn5. The effectiveness of metformin administration wasevidenced by its ability to decrease these markers (sepsis severity, inflammatory, and braininjury) and increase Cldn3 and Cldn5 expressions. Here, CLDN3 is linked to Sepsis.