As mentioned above, the Hippo pathway comprises multiple downstream signalling proteins, such as YAP/TAZ, whose activation can endow cells with several hallmarks of cancer,103, 104 leading to uncontrolled cell growth, malignant transformation, acquisition of EMT and confer tumour cell resistance to chemo‐, radio‐ and even immunotherapy.19, 30, 50. This evidence concerns the gene YAP1 and neoplasm.