ESR2 and neoplasm: These analyses also showed an enrichment for hypomethylated binding sites of transcription factors (e.g., ESR1, ESR2, FOXA2) and histone proteins (e.g., H3K4m1, H3K4m2, H3K4m3, H3K27m3, H3K9m3) in GBM2 compared to GBM1, suggesting a role for these factors in tumor progression (Kondo et al. 2004; Steward et al. 2006).