TARDBP and amyotrophic lateral sclerosis: As described in detail below, the whole spectrum of TDP-43-ir inclusions present in ALS–TDP, FTLD–TDP type B, and type C (i.e., diffuse and compact NCI, DN, and GCI) was consistently and strongly labeled by pTDP-43S375 antiserum, whereas the vast majority of inclusions in all anatomical regions examined in FTLD–TDP type A cases (i.e., diffuse and compact NCI, DN, NII, and WM treads) was not detected by pTDP-43S375 antiserum (Table 2; Figs. 2, 3, 4, 5).