Because it was reported that an increased BC risk was associated with a high dietary glycemic load (23), which has been reported to be reduced by the postprandial glucose and insulin responses to whole grain intake (61), the authors suggested that any potential benefit of whole grain intake to BC risk may act by mitigating the carcinogenic effects of hyperglycemia and hyperinsulinemia (62–64). This evidence concerns the gene INS and Hyperinsulinemia.