TNF and ovarian carcinoma: In the case of EOC, neutrophils coordinate with TNF-α/IL-17 signalling to promote ovarian cancer progression,15 as well as facilitate ovarian cancer premetastatic niche formation through neutrophil extracellular traps (NETs).16 Moreover, neutrophils obtained an inhibitory phenotype in response to supernatants from the ascites of newly diagnosed advanced EOC patients.17 However, the role of TANs in regulating T-cell responses in EOC remains elusive.