LIMS1 and cancer: We observed an increase of the stiffness and a decrease or increase of the power law exponent with increasing force application repeatedly in cancer cells, such as MDA-MB-231 and MCF-7 cells, as well as in mouse embryonic fibroblasts such as PINCH-1 knock-out (PINCH-1−/−) cells and controls (PINCH-1fl/fl).